Nxgen Wholefoods Whole Bone Matrix – 150 capsules

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Nxgen Wholefoods Whole Bone Matrix – 150 capsules

Product Description

Our ancestors ate bones to sustain great bone strength, flexibility and density. Rich in bio available calcium, phosphorous and other minerals, consuming whole bone may nourish and support the integrity of our own bones and teeth enamel.

Research shows that traditional communities rarely experienced certain physical problems like osteoporosis, bad teeth or cavities, or frequent bone breakage. We believe it is in part to their habits of never wasting any part of the animals they ate – bone became their primary source of calcium. These ancient cultures consumed the organs, bones, and connective tissue – anything that wasn’t used for something else was eaten.

Skeletal bone is an organ, placing it in the same nutritional realm as liver, heart, brain, kidney, and sweetbreads. – Mark Sisson.

NXGEN Whole Bone Matrix is made using leg bones from 100% Australian Lake Eyre Beef Bones. Selected Grass Fed Bones are ground into bone chips approximately 10mm in size. Following this the bone chips are cleaned with a low temperature enzyme in water to remove any non-bone tissue and marrow fat. The cleaned bone chips are then vacuum dried over a 24 hour period to remove moisture and retain heat sensitive nutrients. Finally, the dried bone is milled into a fine powder for encapsulation.

Whole Bone has the ideal physiological ratio of calcium and phosphorus (2:1) in a microcrystalline structure that enhances absorption and bioavailability. Unlike alternative synthetic calcium supplements whole bone is a source of naturally occurring growth factors and cytokines from a pure food source and contains type I collagen, essential trace minerals, and bone stimulating peptides (IGF I & II, TGF β,Osteocalcin) that nourish and support the whole skeletal system for strength, flexibility, and remineralisation of our bones and enamel.*

Calcium and Phosphorous in the ideal physiological ratio of 2:1

Whole Bone contains calcium and phosphorus in the ideal physiological ratio of 2:1.  This harmonious ratio allows the body to retain its optimal mineral balance.  Supplementing with calcium alone can lead to mineral deficiencies and other health problems.

The main function of phosphorous is for the formation of strong bones and teeth. It is also necessary for the body to synthesise protein to support the growth, maintenance, and repair of cells and tissues. It even plays an important role in how the body uses carbohydrates and fats and is needed for proper absorption of calcium.

Calcium plays a key role for strengthening bones and teeth, regulating muscle function, blood clotting, the transmission of nervous system messages, and enzyme function.

Bone Stimulating Peptides (IGF I & II, TGF β, Osteocalcin)

Peptides are tissue-specific information molecules, which influence gene expression.  They start the process of protein synthesis in cells, and regulate proper cellular functioning. Our organs, including our bones, consistently produce peptides, but as we age and are impacted by a number of different stressors (environmental toxins, poor nutrition, stress, etc.) our organs will naturally decrease protein synthesis and no longer be able to form new peptides at the same rate as during our youth. Deficiency of these nutrients results in cellular dysfunction, degenerative diseases, accelerated ageing, and bone loss.  One of the most effective ways to counter this deficiency is the consumption of bone specific peptides.

Microcrystalline Hydroxyapatite (MCHA)

In dentistry and oral care products, hydroxyapatite (HA) is a stable and biocompatible calcium phosphate with low solubility being used for various applications such as tooth remineralisation, reduction of tooth sensitivity, oral biofilm control, and tooth whitening.

Hydroxyapatite is a type of calcium that occurs naturally in your body. This calcium-infused constituent comprises almost 70% of your bones and is also the main mineral present in your tooth enamel. When your dentists tells you that you have a weak enamel, what they actually mean is that it has lost all of its hydroxyapatite molecules.

Rather than use synthetically manufactured hydroxyapatite molecules, we can use what nature so generously provided for us in wholefood form.


For joint and bone health, it has been proven that the oral ingestion of collagen daily decreases the joint pain and increases the bone mass density after 4-24 weeks (Moslowitz, 2000).

Castello-Branco et al carried out a clinical study and found microcrystalline hydroxyapatite (MCHA) from whole bone is considered to be more effective than calcium supplements in maintaining bone mass in postmenopausal women. In addition, they suggest it improves pain symptoms and accelerates fracture consolidation in patients with osteopenia or osteoporosis and is significantly more effective in preventing bone loss than calcium carbonate.

Another study found that hydroxyapatite improved cortical bone thickness in a group of women by 11.6 percent, compared to an improvement of only 7 percent with those who only supplemented with calcium gluconate.

Whole Bone contains approximately 20% by weight of organic matrix comprised primarily of collagen. Collagen is the major structural component of the bone matrix, whereby the majority is type I collagen approximately 90%, with smaller amounts of collagen types III, V, X and XII.

Collagen gives bone its flexibility, whereas the addition of mineral to the collagen network provides bone with its stiffness. Without the addition of mineral to collagen, bone tissue would be very flexible, with properties similar to rubber.  Conversely without collagen, bone is brittle. Thus, varying the amounts and distribution of collagen and mineral provides bone with its ability to balance flexibility and stiffness requirements.

Alterations to the structure of collagen that occur from ageing or genetic abnormalities such as osteogenesis which can compromise the structural integrity of bone tissue and results in a weaker structure with a greater than normal susceptibility to fracture.

The remainder of the whole bone approximately 70% by weight serves as an reservoir for storing 99% of the body’s total calcium, approximately 85% of phosphorus and between 40 and 60% of the body’s sodium and magnesium.  These mineral based ions form crystalline structures surrounding and within the collagen fibres to give bone its stiffness. Bone crystals are predominantly in the form of calcium hydroxyapatite  [Ca10PO4OH2], the primary mineral found in the skeleton. {6]


Bone is the ultimate biomaterial, light, strong and flexible, so that it can adapt to its functional demands and with proper nutrition repair itself. Based on the concept of “like supports like,” consuming Whole Bone Matrix may strengthen and support our own bones*.

The bones of beef cattle owe their great strength and mechanical stability to the special structure of the bone matrix which is synthesised by the osteoblasts (bone cells).

The two essential components of the bone matrix involve a framework of cross-linked collagen, type I collagen. The cross-linking takes place by means of the amino acids lysine and hydroxylysine. The second component is hydroxylapatite (also known as apatite-(CaOH)) which is embedded in the bone matrix (mineralisation of the bones). This structure of the bone is roughly comparable to that of steel-reinforced concrete wherein the properties of the steel framework (corresponding to the collagen) and of the concrete (corresponding to the hydroxylapatite) both complement one another forming an extremely stable structure.

Recommended Usage: Adults can take 3 capsules per day. Children can take one per day.  We recommend taking Whole Bone Matrix with Beef Liver Capsules for Vitamin K2 and Vitamin E to ensure the calcium is deposited in the bones where it is needed most. 

Whole Bone Matrix capsules can also be opened up and sprinkled on your toothbrush in addition to your toothpaste OR incorporated into your favourite DIY Remineralising Toothpaste recipe.

Ingredients: Freeze dried 100% Australian Grass Fed & Finished Beef Whole Bone Matrix, Gelatin Capsule.

*FDA STATEMENT: These statements have not been evaluated by the TGA or Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.


[1]  Ruegsegger. P, Keller. A, Dambacher. MA, (1995) Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females

[2]  Galson. DL, et al (2011) Origins of Osteoblasts

[3]  Castelo-Branco. C, et al (2020) Efficacy and Safety of Ossein-Hydroxyapatite Complex verses Calcium Carbonate to Prevent Bone Loss

[4]  Epstein, O. Kato, Y. Dick, R. and Sherlock, S., (1982) Vitamin D, hydroxyapatite, and calcium gluconate in treatment of cortical bone thinning in postmenopausal women with primary biliary cirrhosis. The American Journal of Clinical Nutrition.

[5] Moskowitz, R.W., 2000. Role of collagen hydrolysate in bone and joint disease. Seminars Arthrit. Rheumat., 30: 87-99.

[6] Fuchs. RK et al (2009), Bone anatomy physiology and adaptation to mechanical loading.  Bone Repair Biomaterials